As medical research continues, there are different theories on the causes of liver disease itching. The pathogenesis of osteoporosis in chronic liver disease is complex and related to both increased bone resorption [Crosbie et al. Evolving concepts of the pathogenesis and treatment of the pruritus of cholestasis E Anthony Jones MD DSc 1, Nora V Bergasa MD 2 P ruritus often complicates the syndrome of cholestasis A complete blood count can provide evidence of an internal condition causing your itch, such as anemia. Pruritus often constitutes a most irritating ailment in patients suffering from chronic liver diseases, especially when cholestasis plays a prominent role. Pruritus, or itch, is a common complaint in patients with cholestatic liver disease. 1999] and reduced bone formation [Collier et al. However, the exact pathophysiology of pruritus in cholestatic liver disease remains unclear and is complicated by the dissimilarity of complaints among patients. Several mechanisms are generally accepted as possible explanations to the underlying basis of itch. Definition and prevalence. In addition, new antipruritic therapeutic strategies have been developed and/or are under evaluation. KEYWORDS: Pruritus, cholestasis, primary biliary cirrhosis, liver disease, treatment Introduction The word cholestasis, derived from the Greek words chole complicated pathogenesis of pruritus in PBC resembles its multiple treatment strategies[1]. Pathogenesis. 1998].Unstable bone remodelling is caused by a number of mechanisms, some of which remain unknown. Khurana S, Singh P. Rifampin is safe for treatment of pruritus due to chronic cholestasis: a meta-analysis of prospective randomized-controlled trials. Liver or kidney disorders and thyroid abnormalities, such as hyperthyroidism, may cause itching. Pruritus is an enigmatic, seriously disabling symptom accompanying cholestatic liver diseases and a broad range of other disorders. Most recently, novel itchspecificneuronal pathways, itch mediators and their relevant receptors have been identified. Pathogenesis and management of pruritus in cholestatic liver disease. Liver Int 2006; 26:943. The understanding of the connection between itching and systemic diseases remains limited. Tests of thyroid, liver and kidney function. Th ere are only 2 general prescriptions: namely to The pathogenesis of pruritus in cholestasis and non-cholestatic liver disease remains elusive, and the causative factor or factors have not been conclusively proven. The observation that pruritus accompanies jaundice has already been made by the ancient Greek physician Aretus the Cappadocian in the 2nd century BC .Today, itch is well known as a frequent and agonizing symptom accompanying many types of liver diseases, particularly those with cholestatic features , , .In these disorders, cholestasis may be due to: It is thought that pruritus in the presence of any type of liver disease has the same pathogenesis, and it This review highlights recent Imam MH, Gossard AA, Sinakos E, Lindor KD. symptom control of itch in liver diseases. Pruritus is an enigmatic, seriously disabling symptom accompanying cholestatic liver diseases and a broad range of other disorders. We also highlight recent developments in the pathophysiology of cholestatic pruritus and the emerging novel therapies. Unfortunately, no specifi c and helpful diet or lifestyle modifi cations are recommended in patients with liver diseases and pruritus. 2002; Gallego-Rojo et al. Pruritus is the most frequently described symptom in dermatology and can significantly impair the patients quality of life. Chest X-rays. J Gastroenterol Hepatol 2012; 27:1150. The exact pathogenesis is not entirely recognized.
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